Postnatal ontogenesis of the circadian clock within the rat liver

At postnatal day 30, all clock genes in the rat liver expressed rhythmic patterns.

• The expression of clock genes in the rat liver begins to show rhythmic patterns starting around postnatal day 10.
• At embryonic day 20, only Rev-Erbalpha and Cry1 exhibited variations, with no clear circadian rhythms in other clock genes.
• By postnatal day 20, significant rhythms were detected in the expression of Per1, Per2, Rev-Erbalpha, and Bmal1.
• The rhythmic expression of all analyzed clock genes was established by postnatal day 30.
• The phase of gene expression rhythms shifted throughout the developmental stages until reaching the adult stage.

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