Gut hormones reduce T cell-caused damage in the intestine

Endogenous GLP-1R and GLP-2R signaling is essential for protecting the intestine from T cell-mediated enteropathy.

• Gut injury from T cell activation is increased in mice lacking GLP-1R or GLP-2R.
• Mice with selective loss of intestinal proglucagon gene expression also show increased intestinal damage.
• Administration of the GLP-2R agonist teduglutide reduces intestinal damage in specific mouse models.
• The GLP-1R agonist semaglutide also alleviates T cell-induced intestinal injury when administered alone or with teduglutide.
• These findings suggest distinct protective roles for GLP-1R and GLP-2R in immune-mediated intestinal injury.

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