Clinical kidney journal

Communication between the gut and kidneys is reduced in people with type 2 diabetes

Updated

Abstract

Oral sodium loading induces more rapid natriuresis than intravenous administration in healthy individuals.

  • Natriuresis is the process of excreting sodium in urine.
  • A gut-kidney feed-forward mechanism may be involved in this response.
  • It is unclear if this physiological response is impaired in type 2 diabetes.
  • The potential role of glucagon-like peptide-1 receptor agonism in restoring natriuresis in type 2 diabetes remains to be investigated.

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