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Gut-liver axis in diabetes: Mechanisms and therapeutic opportunities
How gut and liver interactions relate to diabetes and possible treatments
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Abstract
Disruption of the gut-liver axis is associated with significant metabolic dysfunction in diabetes.
- Gut microbiota dysbiosis and impaired intestinal barrier function may contribute to insulin resistance and hepatic steatosis.
- Increased gut permeability is linked to pro-inflammatory signaling that affects glucose metabolism.
- Emerging pathways involving neuroendocrine circuits and microbial metabolites could play a role in gut-liver interactions.
- Therapeutic strategies targeting the gut-liver axis include microbiota modulation and anti-inflammatory interventions.
- Challenges such as patient heterogeneity and lack of reliable biomarkers may hinder clinical translation of these therapies.
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