The gut microbiome in obesity: new horizons in personalized medicine

Mar 9, 2026Terapevticheskii arkhiv

The gut microbiome in obesity and its potential for personalized treatment

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Abstract

Disturbances in the intestinal microbiota are considered a key modifiable factor in obesity and metabolic disorders.

  • Individuals with obesity may exhibit variability in their microbiota composition.
  • Dysbiosis is associated with altered production of short-chain fatty acids and other microbial byproducts.
  • Chronic inflammation from lipopolysaccharides may link dysbiosis to metabolic disorders.
  • The gut microbiota may influence appetite regulation and eating behavior via the microbiota-gut-brain axis.
  • Current diagnostic approaches for dysbiosis and potential personalized medicine strategies are being explored.

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