Full text is available at the source.
Abstract
Essence
This review argues that gut microbiome changes may help drive systemic inflammation and autoimmune responses linked to Parkinson's disease.
Evidence
This narrative review synthesizes human and preclinical evidence on altered gut microbial composition, immune activation, autoreactive T cells, alpha-synuclein aggregation, and neuroinflammation in Parkinson's disease.
Caveat
As a review drawing heavily on associative human data and preclinical studies, it does not by itself prove that microbiome changes cause Parkinson's disease progression.
Simplified
Gut-Brain Axis