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[Mechanisms by which the gut microbiota regulates depressive disorder via the tryptophan metabolic pathway].
How gut bacteria may influence depression through tryptophan metabolism
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Abstract
The gut microbiota may influence depressive disorder through the regulation of tryptophan metabolism.
- Tryptophan metabolism is affected by intestinal microorganisms, which can alter its balance through inflammation and metabolic products.
- In cases of depression, the kynurenine pathway of tryptophan metabolism is overly activated, leading to harmful metabolites that increase neuroinflammation in the brain.
- Probiotics and traditional Chinese medicine may produce antidepressant-like effects by restoring gut microbiota balance and normalizing tryptophan metabolism.
- Targeted inhibition of kynurenine 3-monooxygenase might reduce neuroinflammation by influencing microglial activity, potentially improving depressive behaviors.
- The interaction between tryptophan metabolism and gut microbiota, linked to inflammation, could be crucial for developing new treatments for depression.
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