Full text is available at the source.
Gut microbiota, kynurenine pathway and mental disorders – Review
Gut Bacteria, Kynurenine Pathway, and Their Links to Mental Disorders
AI simplified
Abstract
The kynurenine pathway may be influenced by gut microbiota, which is associated with several psychiatric disorders.
- The intestine and gut-associated lymphoid tissue serve as the largest immune organ in the human body.
- Disturbances in gut biodiversity may lead to increased gut permeability and systemic inflammation.
- Proinflammatory cytokines can induce enzymes in the kynurenine pathway, resulting in neuroactive metabolites linked to psychiatric disorders.
- Certain bacterial species may directly influence the kynurenine pathway.
- Evidence indicates that probiotics could reduce the toxicity of kynurenine metabolites by affecting proinflammatory cytokines.
- Gut microbiota may represent a potential target for future therapeutic strategies related to psychiatric conditions.
AI simplified