Progress in neuro-psychopharmacology & biological psychiatry

Gut bacteria link metabolism problems and thinking difficulties in schizophrenia

Updated

Abstract

The gut microbiome is associated with behaviors and psychiatric conditions through the gut-brain axis.

  • Communication between the gut microbiome and the central nervous system involves neuronal, endocrine, and immunological mechanisms.
  • Atypical antipsychotic drugs (AAPDs) may alter microbiome abundance, potentially leading to adverse effects or worsening of psychiatric disorders.
  • The gut microbiome's regulatory effects have been noted in several psychiatric disorders, including anxiety and depression.
  • Limited evidence exists regarding the role of microbiota in AAPDs-induced metabolic syndrome and cognitive disorders.
  • Prebiotics and probiotics are recognized tools for managing metabolic disturbances and cognitive deficits.

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Full Text

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