Imbalance in gut bacteria linked to depression in teenagers compared to adults and healthy teens

Adolescent depression differs substantially from adult depression in neurodevelopmental and pathophysiological aspects.

• Gut microbiota dysbiosis is recognized as a key regulator in the microbiota-gut-brain axis.
• The microbial and metabolic signatures associated with adolescent depression are not well defined.
• Understanding these differences may help in developing targeted interventions for adolescent depression.

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