Balancing the mind: Toward a complete picture of the interplay between gut microbiota, inflammation and major depressive disorder

Gut microbiota may significantly influence mood regulation and neurological health, with inflammation as a key mediator.

• The relationship between gut microbiota and major depressive disorder (MDD) involves complex interactions with inflammation.
• Alterations in gut microbiota could be associated with the development of depressive features.
• Inflammation may play a crucial role in modulating communication between the gut and the brain in depression.
• Interventional studies suggest that probiotics might influence gut bacterial composition and alleviate depressive symptoms.
• A comprehensive framework for understanding these interactions could guide future research and therapeutic strategies.

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