Research Progress on Mechanisms of Modulating Gut Microbiota to Improve Symptoms of Major Depressive Disorder

Modulating gut microbiota may effectively alleviate depressive symptoms in individuals with major depressive disorder (MDD).

• Accumulating evidence suggests a close relationship between gut microbiota and the occurrence and progression of MDD.
• Gut microbiota engages in bidirectional communication with the host through the gut-brain axis.
• The microbial community in the intestine influences the host's metabolism, immune system, endocrine system, and nervous system.
• Methods of modulating gut microbiota include probiotic intake, fecal transplantation, and dietary intervention.
• Such modulation has been demonstrated to alleviate depressive symptoms in the host.

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