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Integrative gut microbiota and metabolomics reveals the mechanism of chicory extract in improving metabolic dysfunction-associated steatotic liver disease via gut-liver axis
How chicory extract may improve fatty liver disease by affecting gut bacteria and metabolism through the gut-liver connection
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Abstract
Chicory extract significantly inhibited body weight gain and improved hepatic lipid deposition in mice with metabolic dysfunction-associated steatotic liver disease.
- Chicory extract down-regulated the expression of lipid metabolism-related genes SREBP1 and SCD1 in MASLD mice.
- The diversity and community richness of gut microbiota were significantly affected by chicory extract, suggesting its efficacy depends on gut microbiota presence.
- Plasma taurodeoxycholic acid (TDCA) was identified as a core metabolite associated with chicory extract intervention.
- The level of TDCA was positively correlated with the abundance of microbial bile salt hydrolase, indicating a link between chicory extract and gut microbiota.
- In vitro experiments showed that TDCA inhibited lipid accumulation in hyperlipidemic AML12 cells in a dose-dependent manner.
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