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Abstract
Gut microbiota dysbiosis may play a significant role in epilepsy through the modulation of short-chain fatty acids (SCFAs).
- Epilepsy is defined by the occurrence of at least two unprovoked seizures more than 24 hours apart.
- Short-chain fatty acids are produced by gut microbiota and are important for maintaining gut-brain communication.
- SCFAs help regulate seizures by preserving intestinal barrier integrity and influencing immune responses in the gut.
- These metabolites also impact the structure and function of the blood-brain barrier and may regulate neuroinflammation.
- Understanding the relationship between SCFAs and epilepsy could lead to potential new treatments targeting gut microbiota.
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