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Advances and mechanisms of gut microbiota modulation in enhancing immune checkpoint inhibitor efficacy
How changing gut bacteria may improve the effectiveness of immune checkpoint cancer treatments
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Abstract
Gut microbiota modulation strategies may enhance cancer immunotherapy outcomes.
- The gut microbiota is associated with regulating immune functions and metabolic processes critical for health.
- Immune checkpoint inhibitors (ICIs) can face challenges such as treatment resistance and immune-related adverse events.
- Evidence from mouse models and clinical trials suggests that manipulating gut microbiota could improve ICI effectiveness.
- Strategies like fecal microbiota transplantation and dietary interventions may help optimize therapeutic outcomes and reduce adverse effects.
- Gut microbiota influence immune responses by affecting various immune system components and mechanisms.
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