How Gut Bacteria and Gut Inflammation May Interact in the Gut-Brain Link of Autism

Current studies indicate that neuroinflammation and gut microbiota imbalance are key factors in the development of Autism Spectrum Disorder (ASD).

• ASD is primarily characterized by social deficits and repetitive behaviors, often linked with gastrointestinal dysfunction.
• Neuroinflammation involves elevated levels of pro-inflammatory factors and abnormal activation of glial cells.
• Gut microbiota imbalance is evidenced by dysbiosis and compromised intestinal barrier function.
• The gut-brain axis plays a role in regulating neuroinflammation and synaptic function through various metabolic pathways.
• Modulation of the gut microbiota, such as through fecal microbiota transplantation and probiotics, may improve ASD symptoms.

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