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Understanding the complex function of gut microbiota: its impact on the pathogenesis of obesity and beyond: a comprehensive review
How Gut Bacteria Affect the Development of Obesity and Other Health Issues
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Abstract
Obesity is linked to unique shifts in gut microbiota, including increased pro-inflammatory bacteria compared to non-obese children.
- The gut microbiome is crucial for intestinal health, influencing mucus production and regulating short-chain fatty acid production.
- , or microbiome imbalance, is associated with increased appetite and the development of metabolic disorders that contribute to obesity.
- Childhood obesity is correlated with specific alterations in gut microbiota composition.
- Potential therapeutic approaches include , , synbiotics, and dietary interventions such as Mediterranean and ketogenic diets.
- The integration of microbial metabolites with medications like orlistat and semaglutide may help restore microbial balance.
- Further clinical trials are needed to determine the optimal treatment protocols for adjusting the gut microbiome in obesity management.
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Key numbers
100 million
Obesity prevalence in the USA
Approximate number of obese individuals in the USA.
2 billion
Global obesity rate
Estimated number of individuals worldwide facing issues with excess weight.
62%
62% of hospitalized obese patients
Percentage of obese patients who needed mechanical breathing and had COVID-19-related complications.