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Non-alcoholic fatty liver disease and gut microbial dysbiosis- underlying mechanisms and gut microbiota mediated treatment strategies
Non-alcoholic fatty liver disease and imbalanced gut bacteria: causes and bacteria-based treatments
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Abstract
25% of the world's population is affected by non-alcoholic fatty liver disease (NAFLD), making it the most common chronic liver disorder.
- NAFLD is the leading cause of liver-related hospitalizations and deaths globally.
- Obesity, oxidative stress, and insulin resistance are commonly associated with NAFLD.
- Pre-clinical studies suggest that gut microbiota may play a causal role in the development of NAFLD.
- Dysregulation of the gut-liver axis occurs due to increased intestinal permeability and transport of microbial metabolites into the liver.
- Therapeutic approaches such as probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT) could potentially benefit patients with NAFLD.
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