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The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD)
Connections between gut bacteria and non-alcoholic fatty liver disease
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Abstract
NAFLD is currently the main cause of chronic liver disease in developed countries, with a growing number of patients worldwide.
- Gut bacteria may play a crucial role in the development of fatty liver disease, as shown by experiments using gut microbiota transplants in germ-free animal models.
- Changes in the composition of gut microbiota are associated with NAFLD in affected patients.
- Dysbiosis may disrupt the gut barrier function, allowing bacterial components to enter the liver and potentially cause inflammation.
- Metabolites produced by gut microbiota could influence liver health and modulate susceptibility to NAFLD.
- Manipulation of the gut microbiome through probiotics, prebiotics, or synbiotics may improve liver health in both NAFLD patients and rodent models.
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