Gut bacteria and blood metabolites linked to brain amyloid buildup and thinking abilities in mild memory loss patients

Alterations in gut microbiota and plasma metabolomic profiles may be linked to amyloid pathology and cognitive impairment in patients with mild cognitive impairment.

• The gut-brain axis may play a role in the development of Alzheimer's disease.
• Systemic metabolic dysregulation is associated with cognitive decline.
• Patients with mild cognitive impairment may exhibit specific gut microbiota changes.
• Distinct plasma metabolomic profiles could be related to amyloid pathology.

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