Gut microbiota and probiotic therapy in ADHD: A review of current knowledge

Feb 9, 2021Progress in neuro-psychopharmacology & biological psychiatry

Gut bacteria and probiotic treatments in ADHD: what we know so far

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Abstract

Emerging research indicates that changes in the intestinal microbiota may influence ADHD symptoms.

The etiology of ADHD is complex and involves genetic factors as well as gut microbiota.
Evidence suggests that gut microbiota can affect brain development and neurogenesis.
Numerous studies report potential positive effects of probiotic supplementation on neurodevelopmental disorders, including ADHD.
Currently available clinical studies are mostly inconclusive regarding the effectiveness of microbiota-targeted therapies.
There is a need for more high-quality research to establish robust evidence for interventions aimed at the microbiota in ADHD treatment.

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Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by inattention, impulsivity and hyperactivity. The etiology of the disorder is multi-factorial, with a main focus on genetic factors. However, emerging research shows the involvement of changes and imbalances in the intestinal microbiota. Evidence for the influence of gut microbiota on brain development and neurogenesis is clear. We present a review of emerging research on the microbiota in the ADHD population. The aim of this study was to summarize the current state of knowledge on ADHD, to identify gaps in knowledge, as well as to indicate the directions of new research. Thanks to the researchers that would be possible to better understand the complexity of ADHD etiology, especially the role of the intestinal microbiota in the pathogenesis of the disorder. Pubmed, Scopus and Google Scholar databases were used while writing the review. Numerous studies show that probiotic supplementation can have a positive effect on the course of neurodevelopmental disorders, including ADHD. Unfortunately, clinical studies that were identified are mostly inconclusive, and more high-quality research is needed to produce robust evidence for therapy based on interventions targeting microbiota.

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Gut microbiota and probiotic therapy in ADHD: A review of current knowledge

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