The heart of the matter: How gut microbiota-targeted interventions influence cardiovascular diseases

Apr 2, 2025Pathology, research and practice

How Changing Gut Bacteria May Affect Heart and Blood Vessel Diseases

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Abstract

Imbalances in gut microbiota, known as dysbiosis, are linked to the development and progression of cardiovascular diseases (CVDs).

Gut microbiota plays a significant role in overall health and is associated with various physiological functions.
Dysbiosis may lead to the generation of metabolites that contribute to CVD development.
Therapeutic interventions, such as dietary changes, probiotics, prebiotics, and fecal microbiota transplantation, could alter gut microbiota composition.
Exploring the gut microbiota-CVD connection may lead to new strategies for preventing and treating cardiovascular diseases.

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The human body is habitat to a wide spectrum of microbial populations known as microbiota, which play an important role in overall health. The considerable research has mostly focused on the gut microbiota due to its potential to impact numerous physiological functions and its correlation with a variety of disorders, such as cardiovascular diseases (CVDs). Imbalances in the gut microbiota, known as dysbiosis, have been linked to the development and progression of CVDs through various processes, including the generation of metabolites like trimethylamine-N-oxide and short-chain fatty acids. Studies have also looked at the idea of using therapeutic interventions, like changing your diet, taking probiotics or prebiotics, or even fecal microbiota transplantation (FMT), to change the gut microbiota's make-up and how it works in order to prevent or treat CVDs. Exploring the cause-and-effect connection between the gut microbiota and CVDs offers a hopeful path for creating innovative microbiome-centered strategies to prevent and cure CVDs. This review presents an in-depth review of the correlation between the gut microbiota and CVDs, as well as potential therapeutic approaches for manipulating the gut microbiota to enhance cardiovascular health.

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Abstract

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