The Gut-Skin Connection in Chronic Hives and Other Inflammatory Skin Conditions

Altered gut microbial composition in chronic spontaneous urticaria (CSU) is characterized by reduced diversity and an increase in Proteobacteria.

• The gut microbiome may play a critical role in systemic immune responses as it relates to dermatological diseases.
• Chronic spontaneous urticaria is recognized as a systemic immune condition rather than just a skin disorder.
• Reduced gut microbial diversity and depletion of short-chain fatty acid-producing bacteria may contribute to increased intestinal permeability in CSU.
• Animal models indicate that modifying gut microbiota can reduce mast cell hyperreactivity and alleviate urticarial symptoms.
• Clinical evidence suggests that probiotics, prebiotics, dietary changes, and fecal microbiota transplantation may be beneficial adjuncts in managing CSU.
• Challenges exist in applying microbiome research to therapies due to individual differences and complex host-microbiome interactions.

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