The Hallucinogen DOI Reduces Low-Frequency Oscillations in Rat Prefrontal Cortex: Reversal by Antipsychotic Drugs

DOI markedly disrupts cellular and network activity in the prefrontal cortex (PFC) of anesthetized rats.

• DOI altered pyramidal cell activity in the medial PFC, with 39% of cells becoming more active, 27% less active, and 34% showing no change.
• Low-frequency oscillations in the PFC were significantly reduced after DOI administration, with power spectrum values decreasing from .25 to .14 microV(2).
• The change in low-frequency oscillations and the disruption of pyramidal discharge timing were reversed by the 5-HT(2A) receptor antagonist M100907.
• Thalamic lesions did not mitigate the effects of DOI, suggesting the changes originate within the PFC.
• Antipsychotic drugs haloperidol and clozapine reversed the reduction in low-frequency oscillations induced by DOI.

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