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Disruption of thalamocortical activity in schizophrenia models: relevance to antipsychotic drug action
Disrupted communication between the thalamus and thinking areas in schizophrenia models and its link to antipsychotic drugs
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Abstract
Non-competitive NMDA receptor antagonists can significantly disrupt prefrontal cortex function.
- Both phencyclidine (PCP) and the serotonergic hallucinogen DOI increase pyramidal neuron discharge and reduce low frequency cortical oscillations in the prefrontal cortex.
- PCP increases c-fos expression in excitatory neurons across various cortical areas, the thalamus, and the amygdala.
- Electrophysiological studies indicate PCP alters the function of thalamic nuclei that connect with the prefrontal cortex, suggesting a link to psychotomimetic effects.
- The effects of PCP on prefrontal cortex activity may relate to its psychotomimetic properties, as they are prevented or reversed by antipsychotic drugs clozapine and haloperidol.
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