Healthy lifestyles and risk of major non-communicable chronic diseases and mortality in individuals with metabolic syndrome

Aug 20, 2025The journal of nutrition, health & aging

Healthy lifestyles linked to lower risk of major chronic diseases and death in people with metabolic syndrome

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Abstract

During a median follow-up of 11.0 years, 19,435 major non-communicable chronic diseases and 3,578 deaths were recorded in a study of 49,891 individuals with metabolic syndrome.

  • Higher adherence to healthy lifestyle factors is significantly associated with lower risks of major chronic diseases and all-cause mortality.
  • Participants with 6-7 healthy lifestyle factors had a 28% lower risk of major chronic diseases and a 39% lower risk of mortality compared to those with 0-3 factors.
  • Using a weighted lifestyle score, the very healthy group showed a 27% lower risk of major chronic diseases and a 40% lower risk of mortality compared to the very unhealthy group.
  • The population-attributable risks associated with all seven healthy lifestyle factors were 20.72% for major chronic diseases and 26.93% for all-cause mortality.

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