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Regulation of hedonic feeding rhythms by circadian clocks in leptin-receptive neurons
Daily control of pleasure-driven eating by body clocks in fat-signal-sensitive brain cells
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Abstract
Leptin deficiency in mice leads to increased hedonic appetite during the early rest phase.
- Hedonic appetite is specifically heightened in leptin-deficient mice during early rest.
- Clock-deficient mice show reduced rhythmicity in both hedonic and homeostatic appetite control.
- Disruption of clock function in leptin-sensitive neurons results in lower sensitivity to palatable food.
- Mice with clock function disruption exhibit reduced initial weight gain and less adipose tissue growth on a high-calorie diet.
- A local clock-controlled mechanism in the central nervous system may regulate food intake and metabolic balance.
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