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High-Choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction
High-Choline Diet Worsens Heart Function, Scarring, and Inflammation in a Mouse Model of Heart Failure with Normal Pumping
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Abstract
A high-choline diet exacerbates cardiac dysfunction in mice with heart failure with preserved ejection fraction (HFpEF).
- Diastolic dysfunction, left ventricular hypertrophy, and pulmonary congestion were significantly worse in HFpEF mice fed high-choline diets compared to those on a control diet.
- Myocardial fibrosis and inflammation increased markedly in HFpEF mice consuming high-choline diets.
- Treatment with 3,3-dimethyl-1-butanol improved cardiac diastolic function and reduced myocardial fibrosis and inflammation in high-choline diet-fed HFpEF mice.
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