High coffee intake, but not caffeine, is linked to lower risk of estrogen receptor negative and postmenopausal breast cancer regardless of CYP1A2 gene type

A significant reduction in breast cancer risk is observed with high coffee consumption (≥5 cups per day) at a multivariate-adjusted odds ratio of 0.71.

• Generally, coffee and caffeine were not associated with breast cancer risk.
• The highest category of coffee consumption showed a significant risk reduction compared to non-consumers.
• High coffee intake was linked to a decreased risk of ER- breast cancer, with a multivariate-adjusted odds ratio of 0.41.
• Postmenopausal women with high coffee consumption had a reduced breast cancer risk, reflected in an odds ratio of 0.63.
• The genetic variant rs762551 in CYP1A2 did not modify the associations between coffee consumption and breast cancer risk.
• Further studies are needed to confirm these findings.

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