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High fat diet induced obesity alters endocannabinoid and ghrelin mediated regulation of components of the endocannabinoid system in nodose ganglia
Obesity from a high-fat diet changes how hunger and pleasure signals control the nerve cluster that senses body signals
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Abstract
High fat diet (HFD) mice show altered expression of key receptors and enzymes involved in satiety signaling compared to standard diet (SLD) mice.
- In SLD mice, mAEA increased the mRNA levels of the TRPV1 channel and the enzyme FAAH while decreasing the levels of CB1 and GHSR receptors.
- Ghrelin reduced the mRNA content of TRPV1, CB1, and GHSR in SLD mice.
- In HFD mice, mAEA did not affect TRPV1 mRNA levels but increased the mRNA levels of CB1, GHSR, and FAAH.
- Ghrelin decreased TRPV1 mRNA content in HFD mice while increasing CB1 and GHSR mRNA content.
- The changes in receptor and enzyme expression in HFD mice may disrupt vagal afferent signaling related to satiety.
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