Short-term high-fat diet alters postprandial glucose metabolism and circulating vascular cell adhesion molecule-1 in healthy males

Jul 26, 2016Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

Short-term high-fat diet changes blood sugar after meals and levels of a blood vessel inflammation marker in healthy men

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Abstract

The incremental area under the curve (iAUC) of plasma glucose concentration during the meal tolerance test was significantly higher in a low-carbohydrate/high-fat diet (P = 0.009).

  • Short-term intake of a eucaloric low-carbohydrate/high-fat diet may aggravate postprandial glucose metabolism in healthy males.
  • First-phase insulin secretion indexes were significantly lower in the low-carbohydrate/high-fat diet compared to the control diet (P = 0.04).
  • Circulating levels of glucagon-like peptide-1 (GLP-1) were significantly higher in the low-carbohydrate/high-fat diet than in the control diet (P = 0.014).
  • Vascular cell adhesion molecule-1 (VCAM-1) concentrations were also significantly elevated in the low-carbohydrate/high-fat diet compared to the control diet (P = 0.04).
  • No significant differences were observed in metabolites between the intermediate-carbohydrate/intermediate-fat diet and the control diet.

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