A high-fish-oil diet prevents adiposity and modulates white adipose tissue inflammation pathways in mice

The high-fat fish oil diet prevents increased body mass and glucose intolerance in mice compared to the high-fat lard diet.

• The high-fat lard diet led to elevated body mass, adiposity, and glucose intolerance in mice.
• Mice on the high-fat fish oil diet did not show increased body mass or glucose intolerance.
• In white adipose tissue, the high-fat lard diet was associated with insulin signaling defects, macrophage infiltration, and increased inflammatory markers.
• The high-fat fish oil diet reduced insulin resistance and inflammation in white adipose tissue compared to the high-fat lard diet.
• Activation of PPAR and AMPK, and decreases in MAPK and renin-angiotensin system pathways were observed with the high-fat fish oil diet.

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