Impact of high sugar intake on neurobehavioral, oxidative, and hepatic integrity in mice exposed to simulated chronic jetlag/shiftwork

Exposure to chronic circadian disruption and high-sucrose intake in mice resulted in pronounced anxiety, increased body weight, and elevated blood glucose levels.

• Combined circadian misalignment and high-sucrose intake significantly increased anxiety-like behaviors in mice.
• Mice exposed to these conditions exhibited notable increases in body weight and blood glucose levels.
• Histological analysis showed progressive liver damage, including steatosis and lipid accumulation, particularly in mice receiving both stressors.
• Biochemical assessments indicated reduced antioxidant enzyme activity and elevated levels of blood glucose and triglycerides, reflecting oxidative stress and metabolic disruption.
• Circadian disruption alone impaired neurobehavioral outcomes and liver health, while high sugar intake exacerbated these negative effects.

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