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Abstract
Deletion of either Rad6B or Tex1 results in severe defects in gametocyte production and oocyst formation.
- Plasmodium yoelii E2 ubiquitin-conjugating enzymes were systematically profiled for their roles in parasite development.
- The Rad6B-Tex1 complex is crucial for gametocytogenesis and transmission to mosquito vectors.
- Histone H2B monoubiquitination by the Rad6B-Tex1 complex is observed in both Plasmodium yoelii and Plasmodium falciparum.
- This process enhances H3K4 tri-methylation at the promoter of the gene encoding transcription factor AP2-G.
- Induction of AP2-G expression is associated with the initiation of sexual commitment in malaria parasites.
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