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Host/microbiota interactions-derived tryptophan metabolites modulate oxidative stress and inflammation via aryl hydrocarbon receptor signaling
Tryptophan metabolites from host and gut bacteria influence oxidative stress and inflammation through aryl hydrocarbon receptor signaling
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Abstract
Aryl hydrocarbon receptor (AhR) is associated with the regulation of redox homeostasis and immune responses.
- AhR is a transcription factor that activates genes involved in various biological processes.
- Research is shifting focus from xenobiotic-induced AhR activation to its response to physiological ligands.
- Host/gut microbiota-derived tryptophan metabolites serve as significant endogenous ligands for AhR.
- AhR signaling pathways can be categorized into canonical and non-canonical mechanisms.
- Evidence suggests that AhR influences oxidative stress and inflammation in conditions like diabetes and kidney disease.
- The review highlights both limitations and potential breakthroughs regarding endogenous AhR ligands derived from tryptophan catabolism.
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