Full text is available at the source.
Gut microbiota-derived tryptophan metabolism mediates renal fibrosis by aryl hydrocarbon receptor signaling activation
Gut bacteria's processing of tryptophan may contribute to kidney scarring through a specific cellular receptor pathway
AI simplified
Abstract
Tryptophan metabolites may activate the aryl hydrocarbon receptor (AHR) in chronic kidney disease (CKD) patients.
- Gut microbiota influences intestinal immunity and homeostasis through metabolites.
- Kynurenine, serotonin, and indole derivatives are key products of tryptophan metabolism affected by gut microbiota.
- AHR is activated by tryptophan metabolites and is involved in various diseases, including CKD.
- Accumulated uremic toxins in CKD patients can activate AHR, potentially influencing disease progression.
- Understanding the link between gut microbiota, uremic toxins, and AHR activation may reveal new therapeutic strategies for CKD.
AI simplified