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Abstract
Tryptophan metabolites may activate the aryl hydrocarbon receptor (AHR) in chronic kidney disease (CKD) patients.
- Gut microbiota influences intestinal immunity and homeostasis through metabolites.
- Kynurenine, serotonin, and indole derivatives are key products of tryptophan metabolism affected by gut microbiota.
- AHR is activated by tryptophan metabolites and is involved in various diseases, including CKD.
- Accumulated uremic toxins in CKD patients can activate AHR, potentially influencing disease progression.
- Understanding the link between gut microbiota, uremic toxins, and AHR activation may reveal new therapeutic strategies for CKD.
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