HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5

Jul 22, 2023Pharmacological research

HPV E7 protein helps cervical cancer grow by changing RNA modification of PAK5

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Abstract

ALKBH5 was significantly upregulated in cervical cancer (CC) and may serve as a valuable prognostic marker.

  • HPV E6/7 oncoproteins affected global m6A modification and specifically increased ALKBH5 expression.
  • Forced expression of ALKBH5 enhanced malignant traits in cervical cancer cells.
  • E7 promoted ALKBH5 expression through mechanisms involving specific histone modifications and post-translational changes.
  • ALKBH5-mediated m6A demethylation increased the expression of PAK5.
  • The m6A reader YTHDF2 bound to PAK5 mRNA, regulating its stability based on m6A presence.
  • ALKBH5 contributed to tumorigenesis and metastasis in cervical cancer by regulating PAK5.

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