Huayu Qutan formula can improve platelet aggregation in acute coronary syndrome rats by regulating gut microbes to drive trimethylamine/flavin containing monooxygenase 3/trimethylamine N-oxide pathway.

Aug 14, 2025Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

Huayu Qutan formula may improve blood clotting in heart attack rats by changing gut bacteria and related chemical pathways

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Abstract

Huayu Qutan formula may inhibit high platelet reactivity in acute coronary syndrome (ACS) rats.

The TMA/FMO3/TMAO pathway was regulated by gut microbes in ACS rats.
Dominant bacteria in ACS rats included Firmicutes, Bacteroidetes, and Actinobacteria.
The Huayu Qutan formula group exhibited a different microbial composition, with Synergistetes and Deferribacteres being predominant.
A correlation was observed between gut microbiota and metabolic pathways, including riboflavin and arachidonic acid metabolism.
The study suggests potential for Huayu Qutan formula to modulate gut microbes and improve platelet aggregation.

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OBJECTIVE: To investigate the effects of gut microbes regulation of the trimethylamine (TMA)/flavin containing monooxygenase 3 (FMO3)/trimethylamine N-oxide (TMAO) pathway on platelet aggregation in acute coronary syndrome (ACS) rats and the intervention of Huayu Qutan formula.

METHODS: The ACS rats with syndrome of phlegm and blood stasis rats were established. Platelet, platelet aggregation, platelet activation markers and TMA/FMO3/ TMAO pathway were detected. Metagenomics technology was employed to analyze the characteristics of the gut microbiota.

RESULTS: Huayu Qutan formula and gut microbes could inhibit high platelet reactivity and regulate the TMA/ FMO3/TMAO pathway. The dominant bacteria in ACS rats including but not limited to the major phyla, Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria, also including some low abundance phyla, Fusobacteria, Verrucomicrobia, Spirochaetes, and Deferribacteres. The dominant bacteria in the Huayu Qutan formula group were Synergistetes, Deferribacteres, Deferribacteraceae,and. In the Huayu Qutan formula combined with fecal bacteria enema group, the dominant bacteria were Verrucomicrobia, Verrucomicrobiae,and. These gut microbiota were correlated with pathways such as Riboflavin metabolism and Arachidonic acid metabolism. Faecalibacterium Mucispirillum Akkermansia Verrucomicrobium

CONCLUSION: Huayu Qutan formula may prevent ACS by modulating gut microbes Synergistetes,and, regulating the iron metabolism of Deferribacteres, and driving the TMA/FMO3/TMAO pathway to regulate gut microbiota function, and improving platelet aggregation.may serve as a promising probiotic, which could drive TMA/FMO3/ TMAO pathway to regulate Arachidonic acid metabolism to improve platelet aggregation. The findings of this study provide a theoretical basis for the theory of "the heart is connected with the small intestine". Faecalibacterium Allobaculum Akkermansia

Huayu Qutan formula can improve platelet aggregation in acute coronary syndrome rats by regulating gut microbes to drive trimethylamine/flavin containing monooxygenase 3/trimethylamine N-oxide pathway.

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