Advancing Human Circadian Rhythms with Afternoon Melatonin and Morning Intermittent Bright Light

Participants experienced a 2.5-hour phase advance with 0.5 mg melatonin and a 2.6-hour phase advance with 3.0 mg melatonin, compared to a 1.7-hour advance with placebo.

• Both doses of afternoon melatonin resulted in significantly larger phase advances compared to placebo.
• No significant difference in phase advances was observed between the two melatonin doses.
• The combination of afternoon melatonin, morning bright light, and an advancing sleep schedule effectively advanced circadian rhythms by almost 1 hour per day.
• Subjects did not report experiencing symptoms typically associated with jet lag during the treatment period.

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