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Human c GAS Drives LINE ‐1 Transcriptional Activation to Trigger MAVS ‐Dependent Cellular Senescence
Human cGAS Activates LINE-1 to Trigger MAVS-Dependent Cell Aging
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Abstract
Human cGAS is shown to activate L1 transcription by increasing the levels of CTCF and RUNX3.
- L1 retrotransposons can threaten genomic integrity and contribute to inflammation.
- cGAS's role in regulating L1 transcription and its significance is previously unclear.
- cGAS activation of L1 transcription is not observed in mice due to differences in CTCF and RUNX3 function.
- Increased L1 mRNA levels through cGAS activity are linked to cellular senescence via the MAVS pathway.
- This research establishes a connection between cGAS, L1 transcription, and senescence mechanisms.
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