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Relative Hypercoagulopathy of the SARS-CoV-2 Beta and Delta Variants when Compared to the Less Severe Omicron Variants Is Related to TEG Parameters, the Extent of Fibrin Amyloid Microclots, and the Severity of Clinical Illness
Higher Blood Clotting in Beta and Delta COVID-19 Variants Compared to Milder Omicron Variants Linked to Clotting Test Results, Abnormal Clot Proteins, and Illness Severity
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Abstract
Clotting parameters associated with omicron variants are significantly raised compared to healthy controls but lower than those seen with more severe variants.
- Omicron variants of SARS-CoV-2 are linked to increased clotting parameters compared to healthy individuals.
- Clotting levels in omicron infections are significantly lower than those associated with more virulent variants like beta and delta.
- Individuals infected with omicron variants show less extensive formation of fibrin amyloid microclots in platelet-poor plasma.
- The differences in clotting effects among variants may help indicate the relationship between coagulopathy and variant virulence.
- Microclots may be relevant in understanding the severity of symptoms in COVID-19.
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