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Hyperphagia and Increased Fat Accumulation in Two Models of Chronic CNS Glucagon-Like Peptide-1 Loss of Function
Increased overeating and fat gain in two models of long-term loss of brain GLP-1 function
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Abstract
Chronic loss of central nervous system glucagon-like peptide-1 (GLP-1) leads to increased food intake and fat accumulation in rats.
- Knocking down the gene for preproglucagon in a specific brain region resulted in hyperphagia and worsened fat gain and glucose intolerance in rats on a high-fat diet.
- In rats treated with a GLP-1 receptor antagonist, increased food intake occurred alongside fat accumulation and glucose intolerance, regardless of diet type.
- Positive correlation was observed between preproglucagon levels in the brain and fat mass in control rats on a high-fat diet.
- These findings indicate that central GLP-1 is important for regulating energy balance over the long term, differing from its role as a short-term signal for feeling full.
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