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Brain signals of glucagon-like peptide 1 may control when high-fat diets cause insulin resistance and lower energy use
Updated
Abstract
A 1-month blockage of brain GLP-1 signaling completely prevented hyperinsulinemia and insulin resistance in high-fat diet mice.
- Blocking brain GLP-1 signaling may counteract the effects of a high-fat diet on glucose metabolism.
- Increased food intake was observed without a corresponding increase in body weight.
- Brain GLP-1 signaling is associated with reduced energy expenditure through decreased metabolic thermogenesis and ambulatory activity.
- Exendin-9 treatment led to higher levels of thermogenesis, glucose utilization, oxygen consumption, carbon dioxide production, and muscle activity.
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