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Circuits involving the hypothalamic suprachiasmatic nucleus for controlling diverse physiologies verified by the aid of optogenetics and chemogenetics
Brain circuits with the body’s internal clock controlling different body functions confirmed using light and chemical-based methods
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Abstract
Significant progress has been made in understanding the circuits involving the suprachiasmatic nucleus (SCN) that control various physiological functions.
- The SCN is identified as the master circadian pacemaker in mammals.
- Manipulation of neuronal activity within and outside the SCN revealed both expected and previously unrecognized circuits.
- These circuits are associated with functions such as locomotor activity, itch behavior, thirst anticipation, aggression, and food anticipation.
- Optogenetic and chemogenetic techniques have confirmed the SCN's connection to body temperature, heart rate, and insulin sensitivity.
- A fundamental question remains about how the numerous output pathways of the SCN are coordinated.
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