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Network-Mediated Encoding of Circadian Time: The Suprachiasmatic Nucleus (SCN) from Genes to Neurons to Circuits, and Back
How the brain's internal clock system uses genes, nerve cells, and circuits to keep time
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Abstract
The suprachiasmatic nucleus (SCN) functions as a ∼24 h clock both in living animals and in isolated culture.
- The transcriptional architecture of circadian clocks is consistent across different species.
- Mammalian interneuronal mechanisms provide enhanced integration of circadian signals.
- Recent findings explore how electrical activity and calcium levels within SCN neurons relate to intracellular clocks.
- Investigations into neuron and glial cell roles reveal their contributions to the encoding of circadian time.
- Mechanisms at the epigenetic and circuit levels help the SCN convert light signals into daily rhythms.
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