IL-17 in lung disease: friend or foe?

Interleukin 17 (IL-17) is implicated in several chronic inflammatory lung diseases.

• IL-17 is a key proinflammatory cytokine involved in the T helper 17 pathway.
• It plays a role in clearing certain pathogens but may also contribute to inflammatory diseases like rheumatoid arthritis and psoriasis.
• Evidence suggests IL-17 may be involved in neutrophilic inflammation and airway remodeling in chronic respiratory conditions.
• The review examines IL-17's potential roles in asthma, obliterative bronchiolitis, chronic obstructive pulmonary disease, sarcoidosis, and cystic fibrosis.

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