Organ-specific aging measured by imaging predicts human diseases and risk of death

Organ-specific imaging age gaps may mark future organ-related disease and mortality risk.

Observational imaging analysis of 1,777 imaging-derived phenotypes in 11,000 healthy participants estimated biological age for seven organs and linked age gaps with incident diseases, mortality, proteomic signatures, and 14 drug targets.

The abstract reports predictive associations and target nomination, not evidence that changing organ age gaps or acting on the targets improves outcomes.