Full text is available at the source.
Abstract
Autism spectrum disorder (ASD) is associated with altered gut microbiota and chronic low-grade inflammation.
- Gut dysbiosis may compromise intestinal barrier integrity, increasing permeability and allowing harmful substances to enter the bloodstream.
- This condition is linked to the release of inflammatory cytokines, which could activate immune pathways and contribute to neuroinflammation.
- Elevated levels of intestinal biomarkers, such as S100B and calprotectin, are observed in individuals with ASD.
- Fecal microbiota transplantation (FMT) has the potential to restore microbial diversity and enhance the production of beneficial compounds.
- Restoring gut health through FMT may reduce systemic inflammation and improve both gastrointestinal and behavioral symptoms in ASD individuals.
- Current evidence on FMT remains limited by small sample sizes and short follow-up periods, indicating a need for further research.
Simplified