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Do immune system and microbiome–gut–brain axis interactions associate with major depressive disorder?
Are interactions between the immune system and gut-brain communication linked to major depression?
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Abstract
Major depressive disorder (MDD) is a leading psychiatric disorder with increasing global prevalence.
- The immune system and gut microbiota may interact with the central nervous system in complex ways.
- could disrupt both neuroimmune and intestinal immune balance.
- This disruption may lead to impaired intestinal barrier function, resulting in bacterial translocation and systemic inflammation.
- Activation of innate immune pathways, including TLR4 and NLRP3 inflammasomes, is associated with and blood-brain barrier dysfunction.
- Gut microbiota and their metabolites may have neuroprotective effects by facilitating neurotransmitter synthesis and modulating immune responses.
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