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Abstract
The immune infiltration pattern in lower-grade glioma (LGG) is associated with tumor outcomes.
- Immune-related gene (IRG) expression in the tumor microenvironment may influence LGG occurrence and prognosis.
- Three clusters of immune infiltration patterns were identified, with significant associations found between CD8T cells and macrophages and LGG outcomes.
- The Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data (ESTIMATE) algorithm calculated immune and stromal scores from The Cancer Genome Atlas data set.
- Functional enrichment analysis and protein-protein interaction networks were used to explore potential molecular functions of identified IRGs.
- Prognostic values of IRGs were verified using three cohorts from the Chinese Glioma Genome Atlas database.
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