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Profiles of immune‐related genes and immune cell infiltration in the tumor microenvironment of diffuse lower‐grade gliomas
Patterns of immune gene activity and immune cell presence in the environment around diffuse lower-grade brain tumors
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Abstract
The immune infiltration pattern in lower-grade glioma (LGG) is associated with tumor outcomes.
- Immune-related gene (IRG) expression in the tumor microenvironment may influence LGG occurrence and prognosis.
- Three clusters of immune infiltration patterns were identified, with significant associations found between CD8T cells and macrophages and LGG outcomes.
- The Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression data (ESTIMATE) algorithm calculated immune and stromal scores from The Cancer Genome Atlas data set.
- Functional enrichment analysis and protein-protein interaction networks were used to explore potential molecular functions of identified IRGs.
- Prognostic values of IRGs were verified using three cohorts from the Chinese Glioma Genome Atlas database.
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